| 第 35 卷第 4 期 |  | Vol. 35 No. 4 | | 2005 年 8 月 | Aug 2005 |
|
所属栏目：医药及中间体
乙酐法合成乙酰吗啉 |
| 杨建湘; 谢思勉; 庞怀林(吉首大学师范学院; 湖北阳兴天晨化工有限责任公司; 湖南化工研究院; 湖南吉首; 湖北阳兴; 湖南长沙) |
| 摘 要：以乙酐和吗啉为反应原料合成了乙酰吗啉,在吗啉与乙酐摩尔比为1∶1.05、温度110℃、时间2h的条件下反应,经氨中和、脱溶、蒸馏等工序制得乙酰吗啉,与传统方法相比,省去了酸性精馏,收率达97%,产品纯度>99%。 |
| 关键词：乙酰吗啉; 吗啉; 乙酐; 合成 |
| 中图分类号：TQ254 文献标识码：A 文章编号：1009-9212(2005)04-0028-02 |
|
| Synthesis of N-acetylmorpholine |
| YANG Jian-xiang1; XIE Shi-mian2; PANG Huai-lin3 （1. Jishou University Normal College; Jishou 416000; China; 2. HuBei Yangxing chemical Co.; Ltd; Yangxing 435229; 3. Hunan Research Institute of Chemical Industry; Changsha 410007; China） |
| Abstract：N-acetylmorpholine was prepared from morpholine and acetic anhydride via ammonia-neutralization and distillatiou.The optimal conditions of N-aetylmorpholine were as follow:the mole ratio of morpholine and acetic anhydride was 1∶1.05,reaction temperature 110℃,reaction time 2 h.The yield and the purity of N-acetylmorpholine are 97% and 99%,respectively. |
| Key words：N-acetylmorpholine; morpholine; acetic anhydride; synthesis |
|
收稿日期：2005-04-02
|
| 阅读全文 |
|